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Abstract This paper maps research outcomes and identifies spillover effects at a US University Research Center (URC) that offers user facilities for nanotechnology research. We use scientometric and network science approaches to analyze measures of topical orientation, productivity, impact, and collaboration applied to URC-related Web of Science abstract publications records. A focus is on the analysis of spillover effects on external organizations (i.e., non-affiliated users). Our findings suggest the URC’s network relies on external organizations acting as brokers, to provide access to the facilities to other external organizations. Analysis of heterophily indicates that collaboration among internal and external organizations is enhanced by the facilities, while articles written by a mix of co-authors affiliated with internal and external organizations are likely to be more cited. These results provide insights on how URCs with user facilities can create conditions for diverse collaboration and greater research impact.